Blood viscosity and you will hypertension: role of temperatures and you may hyperglycemia

Yildirim Cinar, A great. Mete Senyol, Kamber Duman, Blood viscosity and you may blood pressure level: role from heat and you can hyperglycemia, Western Log out of Blood circulation pressure, Frequency fourteen, Procedure 5, , Profiles 433–438,


We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes best way to find a hookup in New York mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The goal of all of our data is to try to research the relationships certainly one of temperatures, glucose amount, and you can viscosity away from blood and plasma, and determine its consequences with the blood pressure (BP) based on Hagen-Poiseuille’s hydrodynamics picture.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F1 ? F2) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F1 ? F2), where ? is the viscosity of the fluid, F1 and F2 are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Blood viscosity and you can blood pressure: character away from temperature and you can hyperglycemia

It has been shown you to between % and you may % values regarding hematocrit, most of the eleven% boost in hematocrit grows blood viscosity by 20%. Within this state, predicated on Poiseuille’s picture, blood circulation rate reduces from the %, that could produce muscle ischemia. To keep the fresh new circulatory system inside the balance (which is, remaining the fresh move rate adequate and you will stopping structure ischemia), good 20% escalation in BP otherwise 4.66% vasodilation will become necessary. step three However, the human being circulatory method is maybe not a precise signed system, once the blood viscosity is altered on the assimilation off restaurants or drugs. 4–8 In addition, the consequences of dietary fat as well as certain medicines into bloodstream viscosity and hemodynamics eg BP was in fact said. Since the atherosclerotic vessels never dilate well enough just like the a response to vasodilator drugs, it has been recommended one increased blood viscosity can only become compensated which have a beneficial BP rise in such products. 9–twelve In addition to, brand new relationship among BP, horror, coagulation, flow velocity, and you can blood viscosity were described via the standards of hemodynamics. 13, fourteen

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